Phase I study of patients with non-muscle invasive bladder cancer (NMIBC) treated with vesigenurtacel-L (HS-410) after Bacillus Calmette-Guérin (BCG)

نویسندگان

  • Gary Steinberg
  • Neal Shore
  • Lawrence Karsh
  • James Bailen
  • Michael Woods
  • Taylor Schreiber
  • Melissa Price
چکیده

Background Vesigenurtacel-L (HS-410), consists of an allogeneic bladder cancer cell line, selected for high expression of a series of tumor antigens that are known to be shared by a high proportion of bladder tumors. The cell line secretes gp96-Ig, a modified heat shock protein which delivers cellderived antigens to MHC-I via the cross-presentation pathway, leading to preferential activation of CD8+ cytotoxic T cells. Vesigenurtacel-L was evaluated in a Phase I trial after treatment with standard of care induction BCG for safety and immune response.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2015